Genes related to promoters differentially methylated uniquely in Dnmt3aΔIEC mice (e.g., Cdkn2c, Ccn5, Ctnnbip1, and Sfrp5) at day 5 after the initiation of DSS colitis were enriched in processes related to cell junction and cell proliferation (Fig. 7g, Supplementary Data 13). This evidence concerns the gene SFRP5 and colitis.