DNMT3A and Cowden disease: It was the only gene at 2p23.3 to achieve transcriptome-wide significance (Supplementary Data 1; pBonferroni = 0.05/11475 = 4.36 × 10−6 for 11,475 imputable genes), with the negative Z score indicating that the genetic risk variant for CD at this locus is associated with reduced gene expression of DNMT3A.