RAB1A and neoplasm: Based on univariate analysis, the absence of neural invasion (HR = 0.56, P < 0.001) and pCR (HR = 0.28, P < 0.001) were significant predictors of DFS, whereas ypTN stage III vs. 0-II (HR = 1.97, P < 0.001), ypN1-2 vs. ypN0 stage (HR = 2.21, P < 0.001), ypT4 vs. ypT1-3 stage (HR = 1.60, P < 0.001), NCT paradigm of CC vs. IC (HR = 1.77, P = 0.03), and moderately-poorly vs. well differentiated tumor (HR = 1.41, P = 0.02) were significant predictors of disease relapse (Fig. 3a).