RAB1A and neoplasm: Similarly, the absence of neural invasion (HR = 0.55, P < 0.001) and pCR (HR = 0.28, P < 0.001) were significant predictors of DMFS, whereas ypTN stage III vs. 0-II (HR = 2.04, P < 0.001), ypN1-2 vs. ypN0 stage (HR = 2.33, P < 0.001), ypT4 vs. ypT1-3 stage (HR = 1.61, P < 0.001), NCT paradigm of CC vs. IC (HR = 1.85, P = 0.02), moderately-poorly vs. well differentiated tumor (HR = 1.37, P = 0.03), and cN1-2 stage vs. cN0 (HR = 1.34, P = 0.04) were significant predictors of distant metastasis (Fig. 3b).