It would be fascinating to find out in the future whether this “alternate” Hsp90 function is directed by post-translational modifications of Hsp90 or differential co-chaperone influence or the formation of an alternative Hsp90 interactome, an Hsp90 “epichaperome” as suggested for cancer and neurodegenerative diseases80,81. The gene discussed is AQP1; the disease is cancer.