Young et al. found that in the endoplasmic reticulum stress (ER stress) response of breast cancer cells induced by paclitaxel, RNF5 inhibited the mTOR signaling pathway through binding and ubiquitination of SLC1A5/38A2, thus regulating the response of breast cancer to ER stress-induced chemotherapy [23]. The gene discussed is SLC1A5; the disease is breast carcinoma.