Young et al. found that in the endoplasmic reticulum stress (ER stress) response of breast cancer cells induced by paclitaxel, RNF5 inhibited the mTOR signaling pathway through binding and ubiquitination of SLC1A5/38A2, thus regulating the response of breast cancer to ER stress-induced chemotherapy [23]. Here, RNF5 is linked to breast carcinoma.