The data showed that HDAC6 expression was positively correlated with colon cancer metastasis and the tumor stage (Table 1), and that the proportion of infiltrating CD163+CD68+ macrophages was higher in the high-HDAC6 expression group (Fig. 1B), suggesting that the level of HDAC6 expression in tumor cells is related to the proportion of M2 macrophage infiltration. Here, CD163 is linked to neoplasm.