The data showed that HDAC6 expression was positively correlated with colon cancer metastasis and the tumor stage (Table 1), and that the proportion of infiltrating CD163+CD68+ macrophages was higher in the high-HDAC6 expression group (Fig. 1B), suggesting that the level of HDAC6 expression in tumor cells is related to the proportion of M2 macrophage infiltration. This evidence concerns the gene CD68 and colonic neoplasm.