On the other hand, the body weight and fat pads weights of WT and Smyd2+/− mice showed no difference while the food intake of Smyd2+/− mice was significantly higher than that of WT mice, implying that excessive food intake induced obesity may partially offset the weight loss caused by Smyd2 gene knockdown. The gene discussed is SMYD2; the disease is obesity due to melanocortin 4 receptor deficiency.