TNFRSF1A and skin papilloma: Chemical carcinogens, e.g., 7,12-dimethylbenz[a]anthracene and 12-0-tetradecanoylphorbol 13-acetate, induce H-ras-mutant skin papilloma and SCC [10, 11], but deletion of the Tnfrsf1a mouse gene encoding TNFR1 dampens chemical carcinogen-induced skin and liver carcinogenesis [12–16].