UBE2C and sarcomatoid carcinoma: In contrast, silencing TNFR1 reduced levels of stemness, Twist1 (an epithelial–mesenchymal transition–EMT), and oncogenic UBCH10, an E2 ubiquitin-conjugating enzyme [18, 19], converted dedifferentiated spindle cell carcinoma to well-differentiated SCC, and inhibited metastasizing SCCs.