With this differential effect of the used SMAC-mimetics on cIAPs and XIAP inhibition, we aimed to pharmacologically interrogate cIAPs with and without XIAP during primary EBV infection of NOD-scid γc−/− (NSG) mice with reconstituted human immune system components (humanized mice; Fig. 1A). The gene discussed is GC; the disease is Epstein-Barr virus infection.