The biological and clinical significance of Ran‐binding protein 3 (RanBP3) was studied in CRC, and whether NU2058 directly binds to RanBP3 and disrupts RanBP3‐β‐catenin‐c‐Myc/cyclin D1 signaling was investigated. This evidence concerns the gene RANBP3 and colorectal carcinoma.