Knockout of RanBP3 not only markedly enhanced the abilities of CRC cells to proliferate and form colonies (Figure 3D,E) but also increased nuclear accumulation of β‐catenin and the expression of c‐Myc and cyclin D1 (Figure 3F and Figure S3A, Supporting Information), whereas overexpression of RanBP3 had the opposite effect (Figure 3G,I and Figure S3B, Supporting Information). This evidence concerns the gene CCND1 and colorectal carcinoma.