WNK2 and central nervous system cancer: Noteworthy, the WNK2 gene is located at chromosomal region 9q22.31, a region previously linked to familial CRC.34WNK2 somatic mutations are found in several cancer types, including CRC, ovarian, hepatic and gastric cancer.35 36WNK2 has also been reported to be epigenetically silenced in pancreatic adenocarcinoma and gliomas.37 38 Interestingly, WNK2 downregulation has also been detected in serrated polyps.39