TPH1 and rheumatoid arthritis: Tfh numbers within the lymphoid organs of patients with early RA have been demonstrated to correlate with B cell numbers within the same site.21 In our study, we assessed Tph and Tfh cell numbers in the early RA ST and identified positive correlation between Tph and Tfh cells with B cells and GC B cells in follicular regions, and a negative correlation between Tph and Tfh cells in diffuse regions (figure 2D).