Toprofile the antiproliferative effect of functional inverse-agonists,compounds were evaluated in UM-UC-9 bladder cancer cells, which areexquisitively sensitive to PPARγ modulation and possess a focalamplification of the PPARG gene to greater than approximately25 copies.3 Again, para-substitution was strongly preferred, as only BAY-4931 and 6h demonstrated compelling antiproliferative potencyand efficacy (Table 1). This evidence concerns the gene PPARG and urinary bladder carcinoma.