CST3 and chronic kidney disease: There were several metabolic profile changes in response to the glucose challenge characteristic of CKD46 and levels of CKD-associated inflammation markers identified using WGCNA analysis.47 A module consisting of malonate, leucic acid, IMP, kynurenate, uric acid, and inositol had a significant positive correlation with plasma creatinine, plasma cystatin C, CKD status, and a significant negative correlation with eGFR (Fig. 3B).