BCL11A and Schnyder corneal dystrophy: We found that, for the four gRNAs (R-66S, R-02, SD-02, and BCL11A) tested, after 2 weeks of erythroid differentiation of SCD HSPCs, the LDs persisted, and their rates increased (Fig. 3B), demonstrating a significantly reduced level of therapeutic allele compared to that determined using S-R NGS alone.