BCL11A and Schnyder corneal dystrophy: In addition to LDs, R-66S, R-02, SD-02, and BCL11A RNPs induced 3.0 ± 0.1%, 1.1 ± 0.0%, 1.05 ± 0.2%, and 1.5 ± 0.0% large insertions (50 bp to 1.9 kb), respectively, at the Cas9 cut site in SCD HSPCs (Fig. 3C).