In SGA, the receptor profiles of each SGA vary, but for example, 5-HT2A antagonism, 5-HT1A receptor partial agonism, α2b receptor antagonism, and D2 receptor antagonism might improve bipolar depression in quetiapine, and 5-HT7 antagonism might improve bipolar depression in lurasidone (Goldberg 2019; Yatham et al. 2005). This evidence concerns the gene HTR2A and bipolar disorder.