PRC1 and cancer: As proteins involved in bridging fiber nucleation and crosslinking, including HAUS6, HAUS8, and PRC1 have all been linked to various types of cancer (ICGC/TCGA, 2020, retrieved by using cBioPortal Cerami et al., 2012; Gao et al., 2013), it is plausible that impairment of bridging fibers also leads to such increase in lagging chromosomes and contributes to aneuploidy in cancers.