T cells with diminished expression of CD3ζ chain have been found in tumors of patients with non-small cell lung carcinoma and a murine Lewis lung carcinoma (3LL) model, and are accompanied by elevated arginase expression in tumor cells and CAT-2B-mediated arginine uptake in arginase-expressing tumor-associated myeloid cells120. This evidence concerns the gene SLC7A2 and neoplasm.