Regarding endocrine toxicities, 15/39 (38%) of the full effects patients were found to have some form of endocrinological late effect including bone metabolism disorders (Perthe's disease, avascular necrosis, osteochondromas or osteoporosis), delayed growth, insulin abnormalities, adrenal insufficiency, and thyroid abnormalities. The gene discussed is INS; the disease is osteoporosis.