Likewise, a recent study suggested that in lupus nephritis, macrophages metabolism in human and mouse undergoes a shift to glycolysis in answer to IgG immune complex-induced inflammation, this metabolic reprogramming was dependent on the mammalian target of rapamycin (mTOR) and HIF-1α, inhibition of glycolysis caused a decrease in the number of renal macrophages (Ref. Here, MTOR is linked to lupus nephritis.