SLC2A5 and cancer: Finally, our trans complementation experiments demonstrated that full activity of SLC2A5 is necessary for the enhanced proliferation and motility exhibited by cancer cells since the re-introduction of a mutant SLC2A5 defective for fructose binding/transport was unable to restore the phenotype of SLC2A5-attenuated cancer cells to that observed for cancer cells with wild-type SLC2A5.