KDM6A and obesity due to melanocortin 4 receptor deficiency: Notably, feeding and endocrine-related disorders such as feeding difficulties (some cases requiring long-term gastrostomy), gastrointestinal anomalies, tendency to overweight or obesity with age, hyperinsulinism, hypoglycemia, and diabetes insipidus are commonly reported in Kabuki syndrome specifically caused by KDM6A mutations, with male patients (carrying only one X chromosome and thus only one copy of KDM6A) tending to be more severely affected (Lederer et al., 2014; Banka et al., 2015; Gole et al., 2016; Wang et al., 2019; Faundes et al., 2021).