The inflammatory variables were significantly increased in dengue patients with diabetes i.e., CRP (35.308 ± 1.32) mg/dl, Endocan(42.316 ± 1.46) ng/dl, IL-8 (142.98 ± 1.05) pg/ml and Perfusion Index (3.695 ± 0.18) %in comparison with dengue patients without diabetes, CRP (18.6365 ± 0.64) mg/dl, Endocan (32.839 ± 0.33) ng/dl, IL-8 (103.69 ± 0.64) pg/ml and Perfusion Index (1.98 ± 0.08) %. Here, CXCL8 is linked to diabetes mellitus.