In addition, as metastatic clear cell carcinoma of thyroid lacks myoepithelial, positive thyroglobulin staining supports the diagnosis of the tumor of the thyroid and positive chromogranin A, and neuro-specific enolase (NSE) staining supports the diagnosis of the tumor of the glandular carcinoid, but this dual differentiation structure is absent in P-EMC [21]. The gene discussed is ENO2; the disease is thyroid tumor.