Ab42 stimulated PC12 neuronal cells and C6 rat glioma cells: WIN-55,212-2 ↓NO-dependent tau-phosphorylation (Esposito et al., 2006a).Ab42 stimulated hippocampal neuronal and glial co-cultures: URB 602 or JZL184; MAGL Inhibitors ↑s-AG ↓ Ab42-induced neurodegeneration and apoptosis ↓ ERK1/2, NFkb phosphorylation (Chen et al., 2011).Traumatic brain injury PF04457845 (FAAH Inhibitor) ↑)EA ↓tau phosphorylation ↓GSK-3b phosphorylation ↓p35/25 (caspase cleavage products) (Selvaraj et al., 2019). This evidence concerns the gene MAPK3 and central nervous system cancer.