MAPT and central nervous system cancer: ↓Aβ neurotoxicity via inhibiting caspase-3 (Haghani et al., 2012).Ab42 stimulated PC12 neuronal cells↓Ab-induced tau-p ↓GSK3b ↑ Wnt/b-catenin pathway ↑ APP ubiquitination ↓Ab42Via stimulation of PPARg (Vallee et al., 2017). ↓tau-hyper-p Rescue mediated by Wnt/b-catenin pathway (Esposito et al., 2006c).Ab42 stimulated PC12 neuronal cells and C6 rat glioma cells: ↓NO-dependent tau-p (Esposito et al., 2006b).