CRF-overexpressing mice: -Brain atrophy (3–6 months) -Hippocampal dependent learning deficits (9 months) (Campbell et al., 2015a,b).Chronic unpredictable stress (CUS):↑anxiety and depression-like behaviors ↓cognitive performance (Farooq et al., 2012; Campos et al., 2013b,2017). This evidence concerns the gene CRH and major depressive disorder.