PSEN1 and Alzheimer disease: AbPP/PS1 Chronic treatment (i.p. 50 mg/kg; daily for 3 weeks): ↓ soluble Ab40 in hippocampus (Watt et al., 2020).Rat AD model PPARg-dependent: -Reduction in reactive gliosis and neuronal damage -Stimulated hippocampal neurogenesis (Esposito et al., 2011).