GSK3B and Alzheimer disease: CB2R knockout mice -AD-like tau hyperphosphorylation,↑ GSK3β activity ↓ of AMPK activity ↓Sirt1 activity ↓mitochondria dysfunction (Wang et al., 2018).HEK293 tau cells (JWH133) ↓ reduces phosphorylation of tau ↓GSK3β activity AMPK-dependent (Wang et al., 2018).