AbPP/PS1 Chronic THC + CBD Combined Treatment at early OR late symptomatic stages: -Preserved memory -Reduced memory impairment (Aso et al., 2015).5x FAD mice FAAH Inhibitors URB597 or SR1 No effect on Morris Water Maze (Vazquez et al., 2015).Hyperglycemic 3xFAD Mice Chronic low dose AM404 (0.5 μM; GSK-3b inhibitor; AEA Reuptake Inhibitor) Improved learning and memory deficits in Morris Water Maze (Huang et al., 2019). Here, GSK3B is linked to memory impairment.