PPARG and central nervous system cancer: ↓ Inflammation ↓ GFAP and iNOS expression ↓ nitrites, and IL-1b (Esposito et al., 2007a). ↓ reactive gliosis ↓ neuronal damage Effects dependent on PPARg interaction (Esposito et al., 2011).Ab42 stimulated PC12 neuronal cells and C6 rat glioma cells: ↓NO-dependent tau-phosphorylation ↓ nitrite production ↓iNOS expression Inhibition of p-38 Inhibition of MAPK Inhibition of NFkB (Esposito et al., 2006b).Ab42 stimulated PC12 neuronal cells↓oxidative stress ↓mitochondrial dysfunction ↓Reactive Oxygen Species (ROS) (Vallee et al., 2017).