S100B has been implicated in several neurological disorders including TBI (Thelin et al., 2017; Mondello et al., 2021), AD (Cristovao and Gomes, 2019), PD (Angelopoulou et al., 2021), ALS (Serrano et al., 2017), and MS (Barateiro et al., 2016). The gene discussed is S100B; the disease is nervous system disorder.