Elevated levels of NfL in serum have been associated with various neuropathologies such as cognitive decline, TBI, AD, PD, MS, Lewy body dementia (LBD), frontotemporal dementia (FTD), Amyotrophic Lateral Sclerosis (ALS), and Huntington Disease (HD) (Palermo et al., 2020; Rajan et al., 2020; Verde et al., 2021; Chouliaras et al., 2022; Ebenau et al., 2022; Newcombe et al., 2022; Thijssen et al., 2022). The gene discussed is NEFL; the disease is amyotrophic lateral sclerosis.