Increased levels of serum NSE has also been associated with disease severity as mentioned previously with other biomarkers specifically in a cohort of COVID-19 patients who developed dyspnea (Cione et al., 2021), in critical cases of COVID-19 patients (Wei et al., 2020), and in patients immediately following hospital admission for COVID-19 infection (Savarraj et al., 2021). The gene discussed is ENO2; the disease is COVID-19.