The stabilities of CREBBP and additionalknown methylated genes in prostate cancer cell lines40 (YTHDF2, GATA2, and HNRNPF) were assessed after 4 h of co-treatment of ebselenand actinomycin D. In these conditions, ebselen treatment increasedthe stability of methylated genes (Figure 3E). This evidence concerns the gene CREBBP and Familial prostate cancer.