MAPK6 and Alzheimer disease: Of these, nine genes had evidence in literature documenting their association with AD (Figure 1B; APOE, CSF1R, ILR4, MAPK6, MAPT, REST, RIPK4, SP3, and TRIB3).52, 53, 54, 55, 56, 57, 58, 59, 60 Particularly notable were MAPT and APOE. Neurofibrillary tangles, one of the primary AD biomarkers, are aggregates of hyperphosphorylated MAPT gene products.61