Similarly, 16 genes overlapped between Discovery and Extension cohorts when using VISPPh2 (one-tailed hypergeometric p ≈ 4.25e−15), of which six have been previously linked to AD pathology (Figure 1B; CCT5, ERBB2, MAPK6, REST, SYNJ1, and TP53).55 The gene discussed is REST; the disease is Alzheimer disease.