TGFB1 and Alzheimer disease: After clustering with a Louvain algorithm, 127 of the 143 candidate genes mapped to significantly enriched pathways (Figure 4), including, among others, (1) mechanisms involved in glial biology (glial-cell-derived neurotrophic factor receptor);83,84 (2) inflammation (regulation of IP-10 production, positive regulation of transforming growth factor β1 (TGFβ1) production, and chemokine signaling), which is known to be dysregulated in AD;61 (3) clearance of protein aggregates (regulation of aggrephagy and MTOR signaling); and (4) extracellular signaling cascades.