For the GeneEMBED candidates, we modulated the levels of their Drosophila homologs in two well-validated Drosophila AD models48, 49, 50 to test the effect of each candidate on neuronal dysfunction caused by amyloid (secreted Aβ42) or Tau (2N4R hTau) in the CNS. The gene discussed is MAPT; the disease is Alzheimer disease.