GPT and Hepatic failure: Later, using a mouse ALF model induced by LPS/D-GalN, we observed severely damaged liver histology and elevated ALT/AST levels in ALF mice, whereas upregulation of miR-125b-5p reversed the impacts of liver failure, in line with a previous study in which miR-125b-5p was proven to protect against paracetamol- and FAS-induced toxicity in hepatocytes (38).