NOD2 and metabolic dysfunction-associated steatohepatitis: TLR-mediated activation of NF-κB and production of proinflammatory cytokines were markedly suppressed in the colonic mucosa of experimental murine colitis upon the activation of NOD2 by MDP (19, 20), which may also protect mice from hepatocarcinogenesis induced by NASH or treatment with DEN/CCl4.