In addition, OC cells overexpressed plasminogen activator inhibitor-1 (PAI-1) and transcription factor DLX4 to induce the expression of IL-8/CXCL5 and IL-1β/CD44 via activating NF-κB signaling, further enhancing tumor-mesothelial cell interactions and facilitating the metastasis (26, 27). This evidence concerns the gene CXCL8 and neoplasm.