FN1 and ovarian carcinoma: Senescent mesothelial cells upregulated the expression of fibronectin (FN) (23) and downregulated the expression of junctional proteins, such as connexin 43, E-cadherin, occludin and desmoglein, leading to destruction of the integrity of the peritoneal mesothelium and makes it easier for the invasion of ovarian cancer (24).