Senescent mesothelial cells upregulated the expression of fibronectin (FN) (23) and downregulated the expression of junctional proteins, such as connexin 43, E-cadherin, occludin and desmoglein, leading to destruction of the integrity of the peritoneal mesothelium and makes it easier for the invasion of ovarian cancer (24). Here, FN1 is linked to ovarian cancer.