In the tumor microenvironment, tumor cells can negatively regulate the functions of tumor-infiltrating T lymphocytes through their association with immunosuppressive cells and the secretion of immunosuppressive cytokines that inhibit tumor-infiltrating T lymphocytes activation by stimulating the expression of multiple inhibitor receptors through binding to cytokine receptors and then triggering signal transducer and activator of transcription (STAT)-dependent signaling pathway (69). The gene discussed is SOAT1; the disease is neoplasm.