In view of the ubiquitous presence of these cells in all our probands, the existence of experienced single and/or polyfunctional memory T cells cross-reactive and quickly reacting to SARS-CoV-2 might be a decisive advantage in successful immune reactions and moderate to mild COVID-19, also in the elderly, considering the immediate attempt of the virus to evade our immune response, by inducing expression of the immunosuppressive cytokine TGF-β (1, 55, 56). Here, TGFB1 is linked to COVID-19.