In the current study, patients were exposed to increased amount of allergens as desensitization treatment continued, and their clinical symptoms improved, however, patients in both treatment groups had increased serum tIgE and sIgE levels, suggesting that severity of a patient’s allergy symptom was not always related to his/her serum IgE level, the underlying mechanism of this observation needs to be further explored. The gene discussed is IGHE; the disease is Allergy.