NF2 and neoplasm: NF2 is a tumor suppressor gene comprised of 17 exons with 2 splicing isoforms that is positioned on chromosome 22q12.2 (4). Alterations in the NF2 gene, which can be caused by mutation, allelic inactivation, splicing alterations, or Chromosome 22 loss, have been implicated in approximately 30-60% of sporadic meningiomas, making it the single most frequent gene alteration in this tumor (5).