Among them, ITGB3BP, ITGB4, and ITGB6 were up-regulated in BLCA; while ITGA1, ITGA10, ITGA5, ITGA7, ITGA8, ITGA9, ITGB1BP2, and ITGB3 were down-regulated genes; they were defined as DE-ITGs. The gene discussed is ITGB3BP; the disease is bladder transitional cell carcinoma.