Previous studies have shown that CXCL11 expression is significantly upregulated in colon adenocarcinoma and that upregulation of CXCL11 expression is associated with better prognosis, and it has been speculated that the contradiction between CXCL11 expression and prognosis may be due to the complexity of regulation (29). The gene discussed is CXCL11; the disease is colon adenocarcinoma.