Meanwhile, three gene mutations (LRP1B, EPHA5, and NTRK2) were also present in NSCLC coexisting with prodromal changes in COPD, whereas the mutation of MLH1 was only noted in one NSCLC patient with COPD, which indicated that these four genes may not solely be related to COPD. The gene discussed is EPHA5; the disease is chronic obstructive pulmonary disease.