By assuming the positive rate of the mutated gene as greater than 20% in the NSCLC coexisting COPD group, and less than 20% in the other two groups as the threshold, five genes, namely APC, CSMD3, POLE, FGF3, and CCND1, were identified as COPD dominant genes. The gene discussed is APC; the disease is chronic obstructive pulmonary disease.