PCSK9 and neoplasm: Human PCSK9 gene, namely, proprotein converse subtilisin/kexin type 9, is mainly synthesized and secreted by the liver and is one of the key modulators of LDLc; besides, PCSK9 is also found to be closely connected with series of pathophysiological processes, like brain development, platelet activation, intestinal physiology, pancreas, and adipose tissue as well as neoplasms [2], suggesting that PCSK9 is the key regulatory target among different diseases.