Furthermore, cardiac function is decreased in mice deficient in lysosome-associated membrane protein-2 (LAMP-2), a protein essential for a terminal event of the autophagic cascade, i.e., autophagosome-lysosome fusion, mimicking the clinical manifestations of Danon disease (autophagic vacuolar myopathy) resulting due to the mutation in LAMP-2 [63, 64]. This evidence concerns the gene LAMP2 and Danon disease.