The majority of ALS-related genes are involved in the regulation of mitophagy, such as superoxide dismutase 1 (SOD1), OPTN, TAR DNA-binding protein 43 (TDP-43), and TBK1 (Rosen et al., 1993; Amin et al., 2020; Liu et al., 2021). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.