A further link between BBB permeability, seizures and CNP is provided by the observations that NT-proCNP levels are reduced in patients with epilepsy (van Vliet et al., 2007; Ceylan et al., 2018); whether the BBB disruption in gbCNP–/– mice is the sole cause of the spontaneous seizures (or a consequence of the seizures) in these mice will require further investigation. The gene discussed is CNP; the disease is epilepsy.