BRAF and cancer: BRAF mutation in position V600E, which carried about 80% of alteration and V600 K about 10–20%, were responsible for development of cancer in young people, mainly the tumors appear in the parts of body that were not commonly exposed to sunlight (Menzies et al., 2012) (Ascierto et al., 2012) (Luu and Price, 2019).