SPHK2 and renal fibrosis: To evaluate the role of Bst1 in the context of fibrosis, we subjected Bst1–/– mice to unilateral IRI, the same method applied to Sphk2–/– mice, and found that Bst1–/– mice developed less renal fibrosis than WT controls (Figures 5A,B and Supplementary Figures 4, 5).