The negative effects of adipokines on NAFLD or NASH include: 1), activation of hepatic stellate cells (ADIPOQ, LEP and RETN); 2), recruitment of macrophages (ADIPOQ and NAMPT); and 3), activation of monocytes (ADIPOQ and RARRES2). The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatohepatitis.