The beneficial effects of hepatokines include 1) improvement of insulin sensitivity (FGF21); 2) prevention of liver fibrosis (FGF21, HMGB1, PST, AHSG and SERPINF1) and 3) reduction of inflammation and lipid accumulation (FGF21, HMGB1 and LECT2). This evidence concerns the gene SERPINF1 and Hepatic fibrosis.