The beneficial effects of hepatokines include 1) improvement of insulin sensitivity (FGF21); 2) prevention of liver fibrosis (FGF21, HMGB1, PST, AHSG and SERPINF1) and 3) reduction of inflammation and lipid accumulation (FGF21, HMGB1 and LECT2). The gene discussed is LECT2; the disease is Hepatic fibrosis.