STAMBP and obesity due to melanocortin 4 receptor deficiency: It has been reported that a unique mouse model (Pomc tm1Kgm) which was unable to generate desacetyl-α-MSH and α-MSH from ACTH 1-39 developed the characteristic melanocortin obesity phenotype, and desacetyl-α-MSH and α-MSH were found to regulate body weight and energy balance in mouse (213).