This is consistent with that p53 transcriptionally activates TP53TG1 when the DNA-damaging agent is used except that tumor-specific promoter CpG island hypermethylation-associated silencing of the lncRNA TP53TG1 occurs in colorectal and gastric cancer cells (Diaz-Lagares et al., 2016). This evidence concerns the gene TP53TG1 and gastric cancer.