MYOC and open-angle glaucoma: However, functional studies reported thus far are not all-inclusive; namely, the secretion property, cellular stress responses, ECM production, cell proliferation and adhesion of mutant myocilins have not been studied together (Gobeil et al., 2006; Jia et al., 2009; Stothert et al., 2014; Yan et al., 2020), thus creating a gap in the understanding of the precise molecular mechanism that leads to POAG for each mutation.