Each consensus class has distinct differentiation patterns, oncogenic mechanisms, tumour microenvironments, and histological and clinical associations.For example, the tumor driving mechanism of the Lump subtype is mainly related to the overexpression of FGFR3, and the Ba/Sq subtype is mainly related to the overexpression of EGFR.In addition, the mutation spectrum of different molecular subtypes is also different. Here, EGFR is linked to neoplasm.