Clinically, the importance of glucose in brain function has been demonstrated in studies during the 1970s of patients experiencing insulin-induced hypoglycemia, where the administration of exogenous glucose was found to dramatically reverse the progressively worsening adrenergic symptoms and neuroglycopenic signs of hypoglycemia (Sokoloff, 1973), as summarized in Table 1, which in the worst case can lead to loss of consciousness (Kalra et al., 2013). This evidence concerns the gene INS and Hypoglycemia.