Over the last decade, other hnRNP proteins have been linked to neurodegenerative disorders and mutations in genes encoding hnRNP-A1, hnRNP-A2/B1, Matrin-3 (MATR3), Fused in Sarcoma (FUS), EWS RNA-binding protein 1 (EWSR1) and TATA-binding protein-associated factor 2N (TAF15) became progressively important in the context of ALS.16-18 These disease-associated hnRNP proteins carry common structural features with TDP-43, including a low complexity sequence domain (LCD) required for protein–protein or protein–RNA interaction.19,20. This evidence concerns the gene MATR3 and amyotrophic lateral sclerosis.