Several studies suggest that its interaction with nNOS contributes to NOS1AP-mediated excitotoxicity, the formation of neuronal processes and probably schizophrenia.50,64,65 More recently, Li et al. have reported a NOS1AP-regulated neuronal cell death downstream of the NMDAR66 and Hashimoto et al. have identified NOS1AP as a tau-binding protein.67 This evidence concerns the gene NOS1AP and schizophrenia.