TARDBP and neuroblastoma: As a consequence, a better strategy might be to identify key transcripts co-regulated by hnRNP proteins that we have previously found to worsen or rescue TDP-43-mediated alterations in flies and human neuronal cells.35,36 In this work, we have therefore compared transcriptome analyses obtained from human neuroblastoma SH-SY5Y cells silenced for TARDBP (encoding TDP-43) and hnRNPs which we previously found were capable of rescuing or worsening TDP-43 toxicity in flies.