It is intriguing that we have observed meaningful changes in the mRNA expression of component of the PSD linked to the NMDAR and of Synapsin-3 linked to the release of GABA, since emerging evidence link the FTD neuropathology with general alteration in several neurotransmitter systems including the glutamatergic and GABAergic systems.86-88. This evidence concerns the gene SYN3 and frontotemporal dementia.