Nonetheless, taken together all the evidence, we believe that our identification of NOS1AP as a co-regulated target by several hnRNP proteins, including TDP-43, and the role of NOS1AP in the synaptic signalling can link this gene to neurological dysfunctions associated with TDP-43 pathology, make this gene a suitable candidate for the development of novel therapeutic strategies in the context of ALS–FTD pathology. Here, NOS1AP is linked to frontotemporal dementia.