VEGFA and early-onset autosomal dominant Alzheimer disease: Prior work has demonstrated increased angiogenic factors such as VEGF and upregulation of pro-angiogenic genes in Alzheimer’s disease,22–24 and pathological angiogenesis may play an important role in vascular remodelling in CAA.25 Of note, the amount of adaptive angiogenesis in CAA and Alzheimer’s disease is likely limited; overall impairments in angiogenesis in Alzheimer’s disease have been reported and Aβ itself may have an antiangiogenic effect.26,27